Dr. Umesh Kumar

Core Faculty Bio


Dr. Umesh Kumar
Institute of Mgmt. Studies, Ghaziabad

Department: Bio Sciences

Experience

12 Years (Research and Academics)

Profile

Dr. Umesh Kumar has done his doctoral thesis entitled "Epigenetic Regulation in Breast Carcinogenesis" in Dr. B. R. Ambedkar Center for Biomedical Research (ACBR), Delhi University (North Campus) in 2013. From his thesis he was able to publish his interesting findings in peer reviewed international journals of repute. Dr Kumar joined Division of Molecular Oncology in Institute of Cytology & Preventive Oncology (ICMR), Noida which was also WHO collaborated South East Asia Referral Laboratory for the Diagnosis of HPV induced Cervical cancer and later he shifted to Dr. B. R. Ambedkar Center for Biomedical Research (ACBR), Delhi University (North Campus) in 2010. After his doctoral thesis He joined Stem Cells Biology Laboratory for his Post Doc in National Institute of Immunology, New Delhi in 2014 where His Scientific Group has published in the field of Epithelial ovarian cancer stem cell in Nature Oncogene. In 2016, he worked in Department of Biochemistry as Scientific Officer for DNA Sequencing and Microarray facility in South Campus, University of Delhi up to July 2017. In August 2017 he joined Molecular Oncology laboratory in Drug Discovery & Development Laboratory, Department of Chemistry, Delhi University. He has studied promoter hypermethylation of important tumor suppressor genes including BRCA1, p16, CDH1, GSTP1, HIC1, MGMT gene in sporadic breast cancer and their correlation with increasing severity of breast lesions. Study indicated pivotal role of epigenetic silencing of specific genes in breast cancer which may serve as potential therapeutic target for breast cancer.
He has received excellent training in various molecular biology techniques including DNA, RNA and protein preparation, PCR, single strand confirmation polymorphism (SSCP), Automated DNA sequencing, Next-Generation Sequencing, methylation specific PCR, RT-PCR, western blotting, EMSA, ELISA, mammalian cell culture, Immunohistochemistry, FISH, FACS and other associated advanced molecular biology techniques.

Awards & Honors

1. FBPS, Lifetime Fellowship awarded by Blue Planet Society Allahabad at Constitutional Club of India, New Delhi 27th December 2017
2. National Green Award, 2017 in the field of Cancer Epigenetics by ESDA (Environment & Social Development Association at Constitutional Club of India, New Delhi.
3. Young Scientist Award in Indian Association for Cancer Research, 2013 at 32nd Annual convention of Indian Association of Cancer Research(IACR)
4. Awarded ICMR-Senior Research Fellowship by Indian Council of Medical Research in 2010 for three years (2010 - 2013)

Areas of Interest

Molecular Biology, Molecular Genetics, Molecular Epigenetics, Cancer Biology, Molecular Medicine, Stem Cell Biology, Translational Oncology, Immunotherapeutics, System Biology, Molecular Diagnostics

Research publications in International Journal:

1. Umesh Kumar, Ujjawal Sharma and Garima Rathi. Reversal of hypermethylation and reactivation of glutathione S-transferase pi 1 gene by curcumin in breast cancer cell line. Tumor Biology 2017 Feb;39(2):1010428317692258
2. Md. Zahid Akhter, Surender Serawat, Vikash Kumar, Umesh Kumar, Veena Kochat, Zaffar Equbal, Sandeep Mathur, Lalit Kumar, Asok Mukhopadhyay. Aggressive serous epithelial ovarian cancer is potentially propagated by EpCAM+CD45+ phenotype. Oncogene. 2018 Jan 30. doi: 10.1038/s41388-017-0106-y
3. Hedau S, Kumar U, Hussain S, Shukla S, Pande S, Jain N, Tyagi A, Despande T, Bhat D, Mir MM, Chakrabvarty S, Singh YM, Kumar R, Somasundaram K, Bharti AC, Das BC. Breast cancer and human papillomavirus infection: No evidence of HPV etiology of breast cancer in Indian women. BMC Cancer. 2011 Jan 20;11(1):27
4. Umesh Kumar, Ujjawal Sharma and Ramesh Chandra. Glutathione S-transferse pi 1 gene methylation: A novel biomarker in Breast Carcinogenesis. Int. J. Sci. Res. & Communi., 2018; (3) 1: 11-14;
5. Kumar U, Hedau, S, Kumar R, Mukherjee U, Kadayaprath G, Das BC. Promoter hypermethylation in GSTP1, HIC1 and CDH1 genes as a marker for early stage triple negative breast cancer (uploaded in Clinical Oncology Springer) in July 2018
6. Umesh Kumar, Garima Rathi, Ujjawal Sharma, Urmi Mukherjee , Geeta Kadayaprath and Ramesh Chandra. Promoter hypermethylation of GSTP1 correlates with hormonal receptor status in Indian breast cancer patients (communicated in in Clinical Breast Cancer, June 2018)
7. Umesh Kumar, Garima Rathi, Sarabjeet Singh, Geetanjali Bugnait, Ujjawal Sharma and Ramesh Chandra. Analysis of promoter hypermethylation and protein expression in O6 methylguanine DNA methyltransferase, gene in cervical carcinogenesis (communicated in Clinical & Translational Oncology, Sept 2018)

Paper presented in International Conferences:

1. Presented a paper on Reversal of hypermethylation and reactivation of GSTP1 in breast cancer cell line using curcumin at World Non Communicable Diseases Congress 2017 organized by School of Public Health, PGIMER, Chandigarh 4th to 6th November 2017.
2. Delivered Invited talk on Epigenetic Regulation in Breast Carcinogenesis in Indian Breast Cancer Conference 2017 organized by Bone Marrow Stem Cell Transplantation Department, Birla Cancer Institute, SMS Hospital, Jaipur at Hotel Lalit, Jaipur on 7th October, 2017.
3. Delivered Mid level Scientist Oration in 12th Asian Clinical Oncology Society Conference & 35th Annual Convention of Indian Association for Cancer Research entitled "Cancer in Asia: Bridging the gaps" organized by All India Institute of Medical Sciences, New Delhi at The Ashok, New Delhi from April 8-10, 2016.
4. Participated in 5th International Conference on Translational Cancer Research organized by MD Anderson Cancer Center, University of Texas, Houston, USA in collaboration with Delhi State Cancer Institute, New Delhi at Vigyan Bhavan, New Delhi from 6th to 9th February, 2014.
5. Participated in 32nd Annual convention of Indian Association for Cancer Research & International Symposium: Infection & Cancer organized by Dr. B R Ambedkar Center for Biomedical Research (ACBR), University of Delhi from 13th -16th February, 2013.
6. Attended a Golden Jubilee Celebrations CME entitled "Molecular Diagnosis of Genetic Diseases" organized by Department of Biochemistry, Postgraduate Institute of Medical Education & Research Chandigarh from December 22-23, 2012.
7. Attended an International Conference entitled "New Horizons in Cancer Research: Biology to Prevention to Therapy Conference" held in Gurgaon, Delhi (NCR) organized by American Association for Cancer Research (AACR) from December 13 -16, 2011.
8. Attended 28th Annual Convention of Indian Association for Cancer research & International Symposium on Emerging Challenges and Approaches in Cancer Biology organized by Indian Institute of Science, Bangalore from February 21st to 24th, 2009.
9. Delivered an Oral presentation in an international conference on "Recent Trends in Interdisciplinary Sciences: Opportunities and Challenges" (RTISOC-2014) organized by Faculty of Sciences, MMC, CCS University, Meerut from February 28th to March 1st 2014.

FDP Organized:

Participated in TEQIP-III sponsored one week Faculty Development Programme on Recent Trends in Translational Medicine, RDTM-2018 organized by Department of Biotechnology, Delhi Technological University, Delhi on March 12-16, 2018.

National Seminars Attended:

1. Participated as organizing committee member in 9th Symposium on Frontiers in Biomedical Sciences -FBR 2014 organized by ACBR, University of Delhi from 14th April to 16th April 2014.
2. Participated as a Co-convenor in the National Seminar on Environmental Challenges of India organized by Environmental and Social Development Association (ESDA) at The Constitutional Club of India, Rafi Marg, New Delhi held on December 27-28, 2017.
3. Participated as a Member of organizing committee in the National Conference on Environmental Challenges for "New India" organized by Dr. Bhim Rao Ambedkar College, University of Delhi and Environmental and Social Development Association (ESDA) in collaboration with CSIR-NEERI and NESA New Delhi at Dr. Bhim Rao Ambedkar College, University of Delhi held on June 2-3, 2017.
4. Participated as a Organizing Member in the National Enviro-Meet organized by Environmental and Social Development Association (ESDA) at Gandhi Peace Foundation,Deen Dayal Upadhyay Marg, New Delhi held on May 7, 2017.

International Seminars Attended:

1. Participated as organizing committee member in 32nd Annual convention of Indian Association for Cancer Research & International Symposium: Infection & Cancer organized by Dr. B R Ambedkar Center for Biomedical Research (ACBR), University of Delhi from 13th -16th February, 2013.
2. Participated as organizing committee member in Biostatistics & Epidemiology in Biomedical Research entitled "Orientation in Medical Research Methodology and Approach of Biostatistical Analysis" at ICPO (ICMR) from 3rd Dec to 5th Dec, 2008.

Workshops Attended:

1. Participated in the training course on Biostatistics & Epidemiology in Biomedical Research entitled "Orientation in Medical Research Methodology and Approach of Biostatistical Analysis" at ICPO (ICMR) from 3rd Dec to 5th Dec, 2008.
2. Participated in the "Seminar and training workshop on Spectral Confocal Laser Scanning Microscopy" conducted at Institute of Cytology and Preventive Oncology (ICMR), Noida from 4th to 6th August, 2008.
3. Participated in the Examiner for Oral Presentation in the National workshop on "Thieme Chemistry: Science of Synthesis" organized by department of Chemistry, University of Delhi, Delhi on September 28, 2018.

FDP Attended:

Participated in TEQIP-III sponsored one week Faculty Development Programme on Recent Trends in Translational Medicine, RDTM-2018 organized by Department of Biotechnology, Delhi Technological University, Delhi on March 12-16, 2018.

Memberships:
1. Associate Member of American Association for Cancer Research (AACR), Philadelphia, USA
2. Member of Indian Association for Cancer Research (IACR), Mumbai, INDIA
3. Member of Association of Basic Medical Scientists (ABMS), PGIMER , Chandigarh, INDIA
4. Patron Member & Executive President, Uttar Pradesh state , Environment & Social Development Association (ESDA), New Delhi, INDIA
5. Associate Member, Cancer Epigenetics Society (CES) Vienna, Europe